McCormack VA, Menya D, Munishi MO, Dzamalala C, Gasmelseed N, Leon Roux M, et al. Chromosomal and genomic variations in esophageal squamous cell carcinoma: a review of technologies, applications, and prospections. Song Q, Jiang D, Wang H, Huang J, Liu Y, Xu C, et al. Influence of mate drinking, hot beverages and diet on esophageal cancer risk in south America. Esophageal cancer: risk factors, screening and endoscopic treatment in Western and Eastern countries. 2017 96:e7600.ĭomper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á. Microvessel density as a prognostic factor in esophageal squamous cell cancer patients: a meta-analysis. Ma G, Zhang J, Jiang H, Zhang N, Zhu Y, Deng Y, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. 2020 51:965–71.įerlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. A multinational assessment of gastric, esophageal, and colorectal cancer burden: a report of disease incidence, prevalence, and fatality. We revealed that TRPV2-PI3K/Akt/mTOR is a novel and promising target for the prevention and treatment of ESCC.įlorea A, Sangaré L, Lowe K. Mechanistically, the driving role of TRPV2 in the progression of ESCC is mainly regulated by the HSP70/27 and PI3K/Akt/mTOR signalling pathways. Conversely, overexpression of TRPV2 could switch the cells to tumorigenesis upon activation of TRPV2. These effects were inhibited significantly by tranilast (120 μM) and abolished by TRPV2 knockout. The pro-angiogenic capacity of the ESCC cells was found to be enhanced profoundly and both tumour formation and metastasis that originated from the cells were substantially promoted in nude mouse models upon the activation of TRPV2. Our study first uncovered that the activation of TRPV2 by recurrent acute thermal stress (54 ☌) or O1821 (20 μM) promoted cancerous behaviours in ESCC cells.
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A series of in vitro and in vivo experiments were conducted to reveal the role of TRPV2 in the tumorigenesis of ESCC.
Western blotting and immunohistochemistry were performed to determine the expression profiles of TRPV2 in the ESCC patient tissues. The transient receptor potential vanilloid receptor 2 (TRPV2) has been found to participate in the pathogenesis of various types of cancers, however, its role(s) in the tumorigenesis of ESCC remain poorly understood.
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